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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Liquiritin, Cisplatin
Phytochemical Name Liquiritin (PubChem CID: 503737 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Reversing Drug Resistance
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Combination Pair ID: 106
Ref_1
Pair Name Liquiritin, Cisplatin
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Up-regulation Expression BECN1 hsa8678
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP8 hsa841
Up-regulation Cleavage CASP9 hsa842
Down-regulation Expression CCNA2 hsa890
Down-regulation Expression CCND1 hsa595
Down-regulation Expression CDK4 hsa1019
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression MAP1LC3B hsa81631
Up-regulation Cleavage PARP1 hsa142
Up-regulation Expression TP53 hsa7157
In Vitro Model SGC-7901 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0520
In Vivo Model 5-week-old male BALB/c-nu mice, weighed 15–18 g, were subcutaneously injected with 2×10⁵ SGC7901/DDP cells in the left flank.
Result Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo
03. Reference
No. Title Href
1 Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. Int J Oncol. 2017 Nov;51(5):1383-1394. doi: 10.3892/ijo.2017.4134. Click
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